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Mechanism of Action - References

1. Shepherd J. The role of the exogenous pathway in hypercholesterolaemia. Eur Heart J Suppl 2001;3(suppl E):E2-E5.

2. Bays H. Ezetimibe. Expert Opin Investig Drugs 2002;11:1587-1604.

3. Turley SD. Dietary Cholesterol and the mechanisms of cholesterol absorption. Eur Heart J Suppl 1999;1(suppl S):S29-S35.

4. Summary of Product Characteristics, Ezetrol. MSP Singapore Company, LLC, 2002.

5. van Heek M, Farley C, Compton DS et al. Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235 and its glucoronide, SCH60663. Br J Pharmacol 2000; 129:1748-1754

6. Davidson MH, McGarry T, Bettis R et al on behalf the Ezetimibe Study Group. Ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia. J Am Coll Cardiol 2002;40:2125-2134.

7. Ballantyne CM, Houri J, Notarbartolo A et al for the Ezetimibe Study Group. Effect of ezetimibe coadministered with atorvastatin in 628 patients with primary hypercholesterolemia: A prospective, randomized, double-blind trial. Circulation 2003;107:2409-2415.

8. Kerzner B, Corbelli J, Sharp S et al for the Ezetimibe Study Group. Efficacy and safety of ezetimibe coadministered with lovastatin in patients with primary hypercholesterolemia. Am J Cardiol 2003;91:418-424.

9. Melani L, Mills R, Hassman D et al for the Ezetimibe Study Group. Efficacy and safety of ezetimibe coadministered with pravastatin in patients with primary hypercholesterolemia: A prospective, randomized, double-blind trial. Eur Heart J 2003;24:717-728.

10. Westergaard H, Dietchy JM. The mechanism whereby bile acid micelles increase the rate of fatty acid and cholesterol uptake into the intestinal mucosal cell. J Clin Invest 1976;58:97-108.

11. Thurnhofer HJ, Schnabel M, Betz G et al. Cholesterol-transter protein located in the intestinal brush-border membrane. Partial purification and characterization. J Clin Invest 1976;58: 97-108.

12. Catapano AL.  Ezetimibe: A selective inhibitor of cholesterol absorption. Eur Heart J Suppl 2001;3(suppl E):E6-E10.

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